Showing entry for Raloxifene


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0019164
Compound NameRaloxifene
Structure
FormulaC28H27NO4S
InchiKeyGZUITABIAKMVPG-UHFFFAOYSA-N
SMILESOc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O
InchiInChI=1S/C28H27NO4S/c30-21-8-4-20(5-9-21)28-26(24-13-10-22(31)18-25(24)34-28)27(32)19-6-11-23(12-7-19)33-17-16-29-14-2-1-3-15-29/h4-13,18,30-31H,1-3,14-17H2
IUPAC[6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone
Molecular Weight473.17
Pubchem Id5035
Chembl IdCHEMBL81
Targets of Information Source
DrugBank DB00481
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 approved; investigational agonist
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 approved; investigational agonist
P50453 BXGT010799 Serpin B9 reviewed Enzyme modulator SERPINB9 approved; investigational -
P04155 BXGT006155 Trefoil factor 1 reviewed Signaling TFF1 approved; investigational -
PDB RAL
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P03372 BXGT006059 Estrogen receptor reviewed ESR1 Nuclear receptor - - - -
Q62986 BXGT016053 Estrogen receptor beta reviewed Esr2 - - - - -
Q14914 BXGT013513 Prostaglandin reductase 1 reviewed PTGR1 Enzyme - - - -
Binding DB 19441
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 20.6 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 557 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 0.37 - - 4.32
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 2.74 - - 4.32
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 22 - 2.4
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 260 - 341
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 22 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 260 - -
reviewed BXGT013346 Phospholipase D1 reviewed PLD1 - 4300 - -
reviewed BXGT013346 Phospholipase D1 reviewed PLD1 - 3400 - -
reviewed BXGT013346 Phospholipase D1 reviewed PLD1 - >20000 - -
reviewed BXGT013346 Phospholipase D1 reviewed PLD1 - - - 8500
reviewed BXGT013346 Phospholipase D1 reviewed PLD1 - - - 10000
reviewed BXGT011358 Ubiquitin-conjugating enzyme E2 N reviewed UBE2N - 14164 - -
reviewed BXGT011358 Ubiquitin-conjugating enzyme E2 N reviewed UBE2N - 17531 - -
reviewed BXGT012931 Bcl-2-related protein A1 reviewed Bcl2a1 - >20000 - -
reviewed BXGT013346 Phospholipase D1 reviewed PLD1 - 12000 - -
reviewed BXGT004115 Phospholipase D2 reviewed PLD2 - 5000 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 0.72 - -
reviewed BXGT012869 Aldehyde oxidase reviewed Enzyme AOX1 - 3 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 4 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 43 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 10 - - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 0.22 - - -
reviewed BXGT016053 Estrogen receptor beta reviewed Esr2 - 470 - -
reviewed BXGT006424 Estrogen receptor reviewed Esr1 - 7 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 15 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 0.7 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 12 - -
reviewed BXGT016053 Estrogen receptor beta reviewed Esr2 - 3.4 - -
reviewed BXGT006424 Estrogen receptor reviewed Esr1 - 0.7 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 1.8 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 0.4 - - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 4.3 - - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 7 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 470 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 18.9 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 0.73 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 1.6 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 0.89 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 1.9 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 4.5 - - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 0.03 - - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 0.46 - -
reviewed BXGT012869 Aldehyde oxidase reviewed Enzyme AOX1 2.3 - - -
reviewed BXGT012869 Aldehyde oxidase reviewed Enzyme AOX1 0.87 - - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 8.2 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 22
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 23 - - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 2 - - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 0.47 - -
reviewed BXGT009067 Cruzipain reviewed - - >60000 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 24 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 222 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 0.2 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 0.34 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 2 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 7.7 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 0.3 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 6.9 - -
reviewed BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B 69 - - -
reviewed BXGT022402 Aldehyde oxidase 1 reviewed Aox1 - 1100 - -
reviewed BXGT015373 Aldehyde oxidase 1 reviewed AOX1 - 500 - -
reviewed BXGT004731 Aldehyde oxidase 1 reviewed Aox1 - 500 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 170 - -
reviewed BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed SIGMAR1 38 - - -
reviewed BXGT013543 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase reviewed Enzyme EBP 1 - - -
reviewed BXGT009627 C-8 sterol isomerase reviewed ERG2 66 - - -
reviewed BXGT009067 Cruzipain reviewed - - 128000 - -
reviewed BXGT009067 Cruzipain reviewed - - 33000 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 0.38 - - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 0.37 - - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 2.74 - - -
reviewed BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 750 - - -
reviewed BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 9900 - - -
reviewed BXGT005128 Nuclear receptor subfamily 1 group I member 2 reviewed Nuclear receptor NR1I2 - - - 11710
reviewed BXGT019727 Bile acid receptor reviewed Nuclear receptor NR1H4 - 11560 - -
CHEMBL CHEMBL81
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 2511 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 1 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ratio '=' 7 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ratio '=' 7 -
Q9HAW9 BXGT020510 UDP-glucuronosyltransferase 1-8 reviewed - UGT1A8 Activity - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 AC50 '=' 7943 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki '=' 0 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Activity - - -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Activity - - -
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C Ki '=' 617 nM
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 IC50 - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B IC50 '=' 3698 nM
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 Ki - - -
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 IC50 - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 IC50 - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 12589 nM
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA Ki - - -
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG IC50 - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Kinact '=' 0 min-1
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D Ki '=' 478 nM
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 IC50 - - -
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR IC50 - - -
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 Ki - - -
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA Ki - - -
P70245 BXGT011664 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase reviewed - Ebp Inhibition - - -
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 Ki '=' 1900 nM
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 Ki '=' 286 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 18 nM
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Uterine weight '=' 52 mg
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 12 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 16353 nM
Q9HAW8 BXGT020509 UDP-glucuronosyltransferase 1-10 reviewed - UGT1A10 Activity - - -
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 IC50 - - -
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 IC50 - - -
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 IC50 - - -
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 IC50 - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 15 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 1258 nM
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 IC50 - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR Ki - - -
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 Ki - - -
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC IC50 - - -
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 IC50 '=' 3989 nM
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 Ki - - -
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 IC50 - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Ki - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 IC50 '=' 3864 nM
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Ki - - -
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 IC50 - - -
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 Ki - - -
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE IC50 - - -
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 Ki - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Ki - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 19952 nM
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 AC50 - - -
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency - 1122 nM
Q13393 BXGT013346 Phospholipase D1 reviewed - PLD1 IC50 '=' 4000 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 22 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Activity - - -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 IC50 '=' 1174 nM
P14902 BXGT008065 Indoleamine 2,3-dioxygenase 1 reviewed - IDO1 Inhibition '=' 0 %
P42345 BXGT010304 Serine/threonine-protein kinase mTOR reviewed Kinase MTOR Potency '=' 23280 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 28183 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 12589 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 22 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Transcriptional activation - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Inhibition - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 AC50 '=' 6309 nM
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 Ki - - -
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a IC50 - - -
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C IC50 '=' 1178 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki '=' 0 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Potency '=' 25118 nM
Q13393 BXGT013346 Phospholipase D1 reviewed - PLD1 IC50 '=' 4300 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Activity - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Activity - - -
P08482 BXGT006775 Muscarinic acetylcholine receptor M1 reviewed - Chrm1 Potency '=' 15848 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki '=' 0 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki '=' 0 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 RBA '=' 0 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Inhibition '=' 120 %
Q99549 BXGT019932 M-phase phosphoprotein 8 reviewed Epigenetic regulator MPHOSPH8 Potency - 37685 nM
O14939 BXGT004115 Phospholipase D2 reviewed - PLD2 IC50 '=' 3400 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 MED '=' 0 mg kg-1
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 MED '=' 0 mg kg-1
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b IC50 '=' 1861 nM
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Bone mineral density '=' 549 mg/cm3
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Bone mineral density '=' 549 mg/cm3
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ratio '=' 0 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ratio '=' 0 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Relative binding affinity '=' 0 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Relative binding affinity '=' 0 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 IC50 '=' 0 nM
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 Ki '=' 750 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Uterine activity '=' 81 %
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Uterine activity '=' 81 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 0 nM
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 IC50 - - -
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Ki '=' 892 nM
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki '=' 1688 nM
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 IC50 - - -
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 IC50 '=' 282 nM
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 IC50 - - -
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 IC50 - - -
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 Ki - - -
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 Ki - - -
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR Ki - - -
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B IC50 '=' 355 nM
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 IC50 '=' 3576 nM
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 Ki - - -
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK Ki - - -
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 IC50 - - -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki '=' 391 nM
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 IC50 '=' 1565 nM
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA Ki - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki '=' 0 nM
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb IC50 - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 IC50 - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 IC50 - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 IC50 - - -
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 IC50 - - -
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S IC50 - - -
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 Ki - - -
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 Ki '=' 641 nM
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR IC50 - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 557 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ratio IC50 '=' 7 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ratio IC50 '=' 7 -
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 35481 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 341 nM
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 Ki - - -
P25779 BXGT009067 Cruzipain reviewed - Potency '=' 28183 nM
P25779 BXGT009067 Cruzipain reviewed - IC50 '>' 60000 nM
Q06278 BXGT012869 Aldehyde oxidase reviewed Enzyme AOX1 Ki '=' 0 nM
P15917 BXGT008169 Lethal factor reviewed - lef Potency '=' 5011 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Uterine activity '=' 24 %
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Uterine activity '=' 24 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki '=' 0 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 0 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 IC50 - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Ki - - -
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R IC50 - - -
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 Ki - - -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Ki - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 7 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 7 nM
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR IC50 - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 IC50 - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 400 nM
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 IC50 - - -
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki '=' 1185 nM
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Potency - 231 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Ki '=' 9900 nM
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit reviewed Transcription factor NFKB1 Potency '=' 12589 nM
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 Ki - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 260 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 501 nM
P16473 BXGT008234 Thyrotropin receptor reviewed G-protein coupled receptor TSHR Potency '=' 31622 nM
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Activity '=' -7 %
Q15392 BXGT013566 Delta(24)-sterol reductase reviewed Enzyme DHCR24 Inhibition - - -
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 2511 nM
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Uterine weight '=' 28 mg
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Bone mineral density '=' 592 mg/cm3
Q15125 BXGT013543 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase reviewed Enzyme EBP Ki '=' 1 nM
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b IC50 '=' 2693 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IA - - -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 IC50 '=' 3 nM
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R Ki - - -
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 IC50 - - -
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 Ki - - -
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 Ki '=' 2342 nM
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR IC50 - - -
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG Ki - - -
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 IC50 - - -
P14902 BXGT008065 Indoleamine 2,3-dioxygenase 1 reviewed - IDO1 IC50 - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Potency '=' 15 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 7943 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 RBA '=' 0 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 RBA '=' 0 -
P32352 BXGT009627 C-8 sterol isomerase reviewed - ERG2 Ki '=' 66 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 14125 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 14125 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Agonist '=' 0 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Agonist '=' 0 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ratio '=' 3 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ratio '=' 3 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ratio '=' 12 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ratio '=' 12 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 8 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 - - -
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 354 nM
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 Ki '=' 38 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 23 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 23 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 0 nM
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A IC50 '=' 1450 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 7 nM
P04062 BXGT006140 Lysosomal acid glucosylceramidase reviewed - GBA Potency - 17782 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 RBA '=' 0 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 RBA '=' 0 -
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Bone mineral density '=' 386 mg/cm3
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Reduction '=' 49 %
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Reduction '=' 49 %
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Activity '=' 30 %
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Activity '=' 30 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 577 nM
Q5FB27 BXGT015373 Aldehyde oxidase 1 reviewed - AOX1 IC50 '=' 500 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki '=' 23 nM
Q06278 BXGT012869 Aldehyde oxidase reviewed Enzyme AOX1 IC50 '=' 3 nM
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 Ki - - -
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 Ki - - -
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Ki - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 AC50 '=' 10000 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki '=' 2 nM
P25094 BXGT009014 Peripheral myelin protein 22 reviewed - Pmp22 Potency - 5102 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 4 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Activity '=' 81 %
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Activity '=' 81 %
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R Ki - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 IC50 - - -
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 IC50 - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Inhibition - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 222 nM
O54754 BXGT004731 Aldehyde oxidase 1 reviewed - Aox1 IC50 '=' 500 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Inhibition '=' 96 %
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Inhibition '=' 96 %
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Efficacy '=' 0 %
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Efficacy '=' 0 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 470 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Relative binding affinity '=' 18 nM
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R Ki - - -
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R IC50 - - -
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R Ki - - -
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 IC50 - - -
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE IC50 - - -
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 IC50 - - -
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC Ki - - -
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 IC50 - - -
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 Ki '=' 1330 nM
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B Ki '=' 69 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 RBA '=' 64 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Efficacy '=' 0 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 20 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IA - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Inhibition '=' 97 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 0 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Activity '=' 24 %
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Activity '=' 24 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 RBA '=' 1 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 RBA '=' 1 -
Q9Z0U5 BXGT022402 Aldehyde oxidase 1 reviewed - Aox1 IC50 '=' 1100 nM
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 Ki - - -
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a IC50 '=' 2204 nM
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D IC50 '=' 973 nM
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 Ki '=' 280 nM
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 Ki - - -
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 IC50 - - -
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 Ki - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 IC50 - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Ratio IC50 '<' 2 -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Kinact '=' 0 /min
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 7943 nM
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Ki '=' 1932 nM
P15127 BXGT008085 Insulin receptor reviewed - Insr IC50 - - -
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 Ki - - -
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 IC50 - - -
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C IC50 '=' 738 nM
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 IC50 - - -
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 IC50 - - -
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 IC50 - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Activity - - -
P25779 BXGT009067 Cruzipain reviewed - IC50 '=' 128000 nM
P25779 BXGT009067 Cruzipain reviewed - IC50 '=' 33000 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 6 nM
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 IC50 '=' 7 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 222 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 222 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Ratio IC50 '=' 2 -
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Uterine weight '=' 203 mg
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 19952 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 AC50 '=' 1258 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Potency '=' 10000 nM
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 Potency '=' 39810 nM
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A IC50 '=' 2111 nM
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 Ki - - -
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR Ki - - -
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 Ki - - -
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 IC50 - - -
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 Ki - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 0 nM
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA IC50 - - -
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b Ki '=' 846 nM
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 Ki - - -
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 IC50 '=' 681 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Activity '=' 22 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Activity '=' 22 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Relative binding affinity '=' 4 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 4 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 4 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 AC50 '=' 25118 nM
Q06278 BXGT012869 Aldehyde oxidase reviewed Enzyme AOX1 Ki - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 43 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 24 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki '=' 10 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Transcriptional activation - - -
P40225 BXGT010168 Thrombopoietin reviewed - THPO Potency '=' 15848 nM
O75604 BXGT005139 Ubiquitin carboxyl-terminal hydrolase 2 reviewed Enzyme USP2 Potency '=' 5011 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 IC50 '=' 470 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 0 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ratio '=' 0 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ratio '=' 0 -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Activity '=' 74 %
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Activity '=' 74 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki '=' 4 nM
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 17782 nM
P40189 BXGT010164 Interleukin-6 receptor subunit beta reviewed Signaling IL6ST Inhibition - - -
P08887 BXGT006835 Interleukin-6 receptor subunit alpha reviewed Signaling IL6R Inhibition - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 1 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 RBA '=' 58 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 RBA '=' 0 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 0 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 RBA '=' 35 -
Q06278 BXGT012869 Aldehyde oxidase reviewed Enzyme AOX1 IC50 '=' 8 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 2 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 1 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 1 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki '=' 4 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Relative binding affinity '=' 1 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Relative binding affinity '=' 1 %
P15207 BXGT008096 Androgen receptor reviewed - Ar IC50 - - -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Uterotrophic effect '=' 155 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Uterotrophic effect '=' 155 -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Ki - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 1 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 AC50 '=' 25118 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Selectivity '=' 7 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Selectivity '=' 7 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 170 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 170 nM
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 BMD '=' 565 mg/cm3
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 BMD '=' 565 mg/cm3
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Agonist '=' 118 %
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Agonist '=' 118 %
Q8VCH6 BXGT018914 Delta(24)-sterol reductase reviewed - Dhcr24 Inhibition - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 AC50 '=' 2511 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Potency '=' 7943 nM
P80456 BXGT011910 Aldehyde oxidase 1 reviewed - AOX1 IC50 '=' 1533000 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 25929 nM
Q13393 BXGT013346 Phospholipase D1 reviewed - PLD1 IC50 '=' 8500 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A IC50 '=' 1664 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ratio '=' 25 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ratio '=' 25 -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Activity '=' 64 %
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Activity '=' 64 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 56 nM
O14939 BXGT004115 Phospholipase D2 reviewed - PLD2 IC50 '=' 10000 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Selectivity '=' 67 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Selectivity '=' 67 -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 IC50 '=' 1 nM
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 IC50 '=' 1 nM
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Wet weight '=' 53 mg
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Wet weight '=' 53 mg
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A IC50 - - -
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR Ki - - -
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 Ki - - -
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 IC50 - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Dose '=' 0 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Dose '=' 0 nM
P42345 BXGT010304 Serine/threonine-protein kinase mTOR reviewed Kinase MTOR Potency '=' 14689 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 AC50 - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 Inhibition - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Inhibition - - -
P15917 BXGT008169 Lethal factor reviewed - lef Potency '=' 12589 nM
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 IC50 - - -
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 IC50 '=' 1869 nM
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA IC50 - - -
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 Ki - - -
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 IC50 '=' 1602 nM
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 Ki '=' 477 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Potency '=' 6309 nM
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S Ki - - -
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 Ki - - -
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R Ki - - -
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 IC50 - - -
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 IC50 - - -
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R IC50 - - -
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A Ki - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 0 nM
P83916 BXGT012025 Chromobox protein homolog 1 reviewed Epigenetic regulator CBX1 Potency - 31622 nM
Q96RI1 BXGT019727 Bile acid receptor reviewed Nuclear receptor NR1H4 IC50 '=' 11560 nM
P15127 BXGT008085 Insulin receptor reviewed - Insr Ki - - -
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 IC50 - - -
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 IC50 '=' 1176 nM
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 Ki - - -
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 IC50 '=' 6644 nM
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 Ki - - -
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 Ki - - -
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 Ki '=' 1485 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 33498 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 25118 nM
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 28183 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Potency '=' 25118 nM
O15648 BXGT004185 ATP-dependent 6-phosphofructokinase reviewed - pfk Potency - 33807 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Inhibition - - -
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 14125 nM
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 Ki - - -
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN IC50 '=' 3666 nM
P70496 BXGT011671 Phospholipase D1 reviewed - Pld1 IC50 '>' 20000 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Inhibition '=' 88 %
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 IC50 '=' 2000 nM
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R IC50 - - -
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE Ki - - -
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 IC50 - - -
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE Ki - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 IC50 - - -
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a Ki - - -
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 22387 nM
P42345 BXGT010304 Serine/threonine-protein kinase mTOR reviewed Kinase MTOR Potency '=' 26121 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 RBA '=' 0 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki '=' 2 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 37685 nM
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 28183 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 - - -
Q06278 BXGT012869 Aldehyde oxidase reviewed Enzyme AOX1 Ki '=' 2 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Activity - - -
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 Ki - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 RBA '=' 100 %
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Activity '=' 4 %
O75469 BXGT005128 Nuclear receptor subfamily 1 group I member 2 reviewed Nuclear receptor NR1I2 max activation '=' 81 %
Q06278 BXGT012869 Aldehyde oxidase reviewed Enzyme AOX1 Ki '=' 0 nM
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 Ki - - -
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN Ki - - -
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK IC50 - - -
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 IC50 - - -
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 Ki - - -
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Ki '=' 1491 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki '=' 624 nM
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 Ki - - -
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 IC50 - - -
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 IC50 - - -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA IC50 - - -
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 Ki - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Ki - - -
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 IC50 - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 - - -
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR IC50 - - -
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR Ki - - -
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R IC50 - - -
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 Ki - - -
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Ki '=' 107 nM
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 Ki - - -
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A IC50 - - -
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A Ki - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Ki - - -
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Ki '=' 414 nM
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 Ki - - -
Q9HAW9 BXGT020510 UDP-glucuronosyltransferase 1-8 reviewed - UGT1A8 Drug metabolism - - -
O75469 BXGT005128 Nuclear receptor subfamily 1 group I member 2 reviewed Nuclear receptor NR1I2 EC50 '=' 11710 nM
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Ki '=' 531 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki - - -
P25094 BXGT009014 Peripheral myelin protein 22 reviewed - Pmp22 Potency - 19937 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 0 nM
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 IC50 - - -
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 IC50 - - -
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 2511 nM
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR Ki - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Inhibition '=' 113 %
Q9XSJ7 BXGT022190 Collagen alpha-1(I) chain reviewed - COL1A1 Activity - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki '=' 0 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 IC50 - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Ki - - -
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA IC50 - - -
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb Ki - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 Ki - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 Ki - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 Ki - - -
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 Ki - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 Ki - - -
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 IC50 - - -
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 Ki - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR IC50 - - -
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B Ki '=' 226 nM
P15207 BXGT008096 Androgen receptor reviewed - Ar Ki - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 260 nM
Q9HAW8 BXGT020509 UDP-glucuronosyltransferase 1-10 reviewed - UGT1A10 Drug metabolism - - -
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Activity - - -
Q96RI1 BXGT019727 Bile acid receptor reviewed Nuclear receptor NR1H4 Inhibition '=' 71 %
P40189 BXGT010164 Interleukin-6 receptor subunit beta reviewed Signaling IL6ST Activity - - -
P42702 BXGT010335 Leukemia inhibitory factor receptor reviewed Signaling LIFR Inhibition - - -
Q06278 BXGT012869 Aldehyde oxidase reviewed Enzyme AOX1 Ratio Ki - - -
Q15125 BXGT013543 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase reviewed Enzyme EBP Inhibition - - -
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF02978 Tetradium ruticarpum Tetradium ruticarpum Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease