protein

Showing entry for Platelet-activating factor acetylhydrolase

General Target Information
BXGT Id	BXGT013310
Protein Name	Platelet-activating factor acetylhydrolase
Uniport Id	Q13093
Gene	PLA2G7
Gene Id	7941
Domain	PAF-AH_p_II
Pfam	PF03403
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
1. Metabolism	1.3 Lipid metabolism	hsa00565	Ether lipid metabolism
1. Metabolism	1.0 Global and overview maps	hsa01100	Metabolic pathways

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0034440	lipid oxidation
Biological Process	GO:0034374	low-density lipoprotein particle remodeling
Biological Process	GO:0034638	phosphatidylcholine catabolic process
Biological Process	GO:0034441	plasma lipoprotein particle oxidation
Biological Process	GO:0062234	platelet activating factor catabolic process
Biological Process	GO:0046469	platelet activating factor metabolic process
Biological Process	GO:0050729	positive regulation of inflammatory response
Biological Process	GO:0090026	positive regulation of monocyte chemotaxis
molecular function	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity
molecular function	GO:0047499	calcium-independent phospholipase A2 activity
molecular function	GO:0016788	hydrolase activity, acting on ester bonds
molecular function	GO:0005543	phospholipid binding
cellular component	GO:0005737	cytoplasm
cellular component	GO:0005576	extracellular region
cellular component	GO:0034364	high-density lipoprotein particle
cellular component	GO:0034362	low-density lipoprotein particle

Reactome

Pathway Id	Pathway Name
R-HSA-2980736	Peptide hormone metabolism
R-HSA-392499	Metabolism of proteins
R-HSA-422085	Synthesis, secretion, and deacylation of Ghrelin

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0001339	BXGD000041	Acute pancreatitis	Digestive System Diseases
C0002395	BXGD000111	Alzheimer's Disease	Nervous System Diseases; Mental Disorders
C0002726	BXGD000125	Amyloidosis	Nutritional and Metabolic Diseases
C0002962	BXGD000160	Angina Pectoris	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003850	BXGD000225	Arteriosclerosis	Cardiovascular Diseases
C0004096	BXGD000252	Asthma	Respiratory Tract Diseases; Immune System Diseases
C0004153	BXGD000260	Atherosclerosis	Cardiovascular Diseases
C0004238	BXGD000262	Atrial Fibrillation	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004606	BXGD000279	Nonproliferative diabetic retinopathy	Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0005750	BXGD000333	Blind Loop Syndrome	Digestive System Diseases; Nutritional and Metabolic Diseases
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0007102	BXGD000425	Malignant tumor of colon	Digestive System Diseases; Neoplasms
C0007193	BXGD000451	Cardiomyopathy, Dilated	Cardiovascular Diseases
C0007194	BXGD000452	Hypertrophic Cardiomyopathy	Cardiovascular Diseases
C0007222	BXGD000454	Cardiovascular Diseases	Cardiovascular Diseases
C0007282	BXGD000458	Carotid Stenosis	Nervous System Diseases; Cardiovascular Diseases
C0007785	BXGD000485	Cerebral Infarction	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0007787	BXGD000487	Transient Ischemic Attack	Nervous System Diseases; Cardiovascular Diseases
C0007820	BXGD000491	Cerebrovascular Disorders	Nervous System Diseases; Cardiovascular Diseases
C0009324	BXGD000597	Ulcerative Colitis	Digestive System Diseases
C0009375	BXGD000602	Colonic Neoplasms	Digestive System Diseases; Neoplasms
C0010054	BXGD000647	Coronary Arteriosclerosis	Cardiovascular Diseases
C0010068	BXGD000648	Coronary heart disease	Cardiovascular Diseases
C0010073	BXGD000650	Coronary Artery Vasospasm	Cardiovascular Diseases
C0011265	BXGD000708	Presenile dementia	Nervous System Diseases; Mental Disorders
C0011847	BXGD000749	Diabetes	Endocrine System Diseases
C0011849	BXGD000751	Diabetes Mellitus	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854	BXGD000753	Diabetes Mellitus, Insulin-Dependent	Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860	BXGD000755	Diabetes Mellitus, Non-Insulin-Dependent	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881	BXGD000760	Diabetic Nephropathy	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0011884	BXGD000762	Diabetic Retinopathy	Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0013595	BXGD000858	Eczema	Skin and Connective Tissue Diseases
C0017661	BXGD001139	IGA Glomerulonephritis	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0019061	BXGD001273	Hemolytic-Uremic Syndrome	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Hemic and Lymphatic Diseases
C0019693	BXGD001346	HIV Infections	Infections; Immune System Diseases
C0020443	BXGD001385	Hypercholesterolemia	Nutritional and Metabolic Diseases
C0020445	BXGD001386	Hypercholesterolemia, Familial	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020473	BXGD001396	Hyperlipidemia	Nutritional and Metabolic Diseases
C0020523	BXGD001417	Immediate hypersensitivity	Immune System Diseases
C0020538	BXGD001422	Hypertensive disease	Cardiovascular Diseases
C0020542	BXGD001425	Pulmonary Hypertension	Respiratory Tract Diseases
C0020557	BXGD001432	Hypertriglyceridemia	Nutritional and Metabolic Diseases
C0020597	BXGD001439	Hypobetalipoproteinemias	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0025286	BXGD001850	Meningioma	Neoplasms; Nervous System Diseases
C0025521	BXGD001876	Inborn Errors of Metabolism	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0026691	BXGD001917	Mucocutaneous Lymph Node Syndrome	Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026769	BXGD001930	Multiple Sclerosis	Immune System Diseases; Nervous System Diseases
C0027051	BXGD001963	Myocardial Infarction	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627	BXGD002006	Neoplasm Metastasis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651	BXGD002009	Neoplasms	Neoplasms
C0027726	BXGD002030	Nephrotic Syndrome	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0028754	BXGD002082	Obesity	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0032460	BXGD002355	Polycystic Ovary Syndrome	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0032580	BXGD002362	Adenomatous Polyposis Coli	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms
C0033036	BXGD002389	Atrial Premature Complexes	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0033860	BXGD002438	Psoriasis	Skin and Connective Tissue Diseases
C0035222	BXGD002513	Respiratory Distress Syndrome, Adult	Respiratory Tract Diseases
C0035309	BXGD002530	Retinal Diseases	Eye Diseases
C0036341	BXGD002600	Schizophrenia	Mental Disorders
C0036690	BXGD002632	Septicemia	Pathological Conditions, Signs and Symptoms; Infections
C0038454	BXGD002760	Cerebrovascular accident	Nervous System Diseases; Cardiovascular Diseases
C0038525	BXGD002768	Subarachnoid Hemorrhage	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0041948	BXGD002939	Uremia	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0042373	BXGD002978	Vascular Diseases	Cardiovascular Diseases
C0085207	BXGD003140	Gestational Diabetes	Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0085580	BXGD003191	Essential Hypertension	Cardiovascular Diseases
C0151744	BXGD003469	Myocardial Ischemia	Cardiovascular Diseases
C0154830	BXGD003746	Proliferative diabetic retinopathy	Pathological Conditions, Signs and Symptoms; Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0155626	BXGD003806	Acute myocardial infarction	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0162871	BXGD003996	Aortic Aneurysm, Abdominal	Cardiovascular Diseases
C0220668	BXGD004317	Congenital contractural arachnodactyly	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0242339	BXGD005150	Dyslipidemias	Nutritional and Metabolic Diseases
C0243026	BXGD005210	Sepsis	Pathological Conditions, Signs and Symptoms; Infections
C0333516	BXGD006957	Tumor necrosis	Pathological Conditions, Signs and Symptoms
C0338656	BXGD007211	Impaired cognition	Mental Disorders
C0340288	BXGD007316	Stable angina	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0342882	BXGD007573	Familial hypercholesterolemia - heterozygous	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0344315	BXGD007666	Depressed mood	Behavior and Behavior Mechanisms
C0376358	BXGD007992	Malignant neoplasm of prostate	Neoplasms; Male Urogenital Diseases
C0376618	BXGD008003	Endotoxemia	Pathological Conditions, Signs and Symptoms; Infections
C0400966	BXGD008266	Non-alcoholic Fatty Liver Disease	Digestive System Diseases
C0403396	BXGD008276	Steroid-sensitive nephrotic syndrome	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0494463	BXGD009029	Alzheimer Disease, Late Onset	Nervous System Diseases; Mental Disorders
C0497327	BXGD009061	Dementia	Nervous System Diseases; Mental Disorders
C0520679	BXGD009101	Sleep Apnea, Obstructive	Respiratory Tract Diseases; Nervous System Diseases
C0524620	BXGD009236	Metabolic Syndrome X	Nutritional and Metabolic Diseases
C0543822	BXGD009296	Atherosclerotic occlusive disease	Cardiovascular Diseases
C0577631	BXGD009535	Carotid Atherosclerosis	Nervous System Diseases; Cardiovascular Diseases
C0598766	BXGD009669	Leukemogenesis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139	BXGD009695	Prostate carcinoma	Neoplasms; Male Urogenital Diseases
C0699790	BXGD009866	Colon Carcinoma	Digestive System Diseases; Neoplasms
C0730285	BXGD009943	Diabetic macular edema	Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0740394	BXGD009989	Hyperuricemia	Pathological Conditions, Signs and Symptoms
C0742343	BXGD010061	Acute Chest Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C0745103	BXGD010114	Hyperlipoproteinemia Type IIa	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0748355	BXGD010195	Acute respiratory distress	Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0751633	BXGD010529	Carotid Artery Plaque	Nervous System Diseases; Cardiovascular Diseases
C0751956	BXGD010653	Acute Cerebrovascular Accidents	Nervous System Diseases; Cardiovascular Diseases
C0852949	BXGD010957	Arteriopathic disease	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0856169	BXGD011096	Endothelial dysfunction
C0917805	BXGD011414	Transient Cerebral Ischemia	Nervous System Diseases; Cardiovascular Diseases
C0947751	BXGD011494	Vascular inflammations	Cardiovascular Diseases
C0948008	BXGD011499	Ischemic stroke	Nervous System Diseases; Cardiovascular Diseases
C0948089	BXGD011504	Acute Coronary Syndrome	Cardiovascular Diseases
C1257915	BXGD011813	Intestinal Polyposis	Digestive System Diseases
C1260873	BXGD011835	Aortic valve disorder	Cardiovascular Diseases
C1269955	BXGD012005	Tumor Cell Invasion
C1270972	BXGD012006	Mild cognitive disorder	Mental Disorders
C1290884	BXGD012198	Inflammatory disorder	Pathological Conditions, Signs and Symptoms
C1306889	BXGD012380	Peripheral arterial occlusive disease	Cardiovascular Diseases
C1449563	BXGD013086	Cardiomyopathy, Familial Idiopathic	Cardiovascular Diseases
C1504438	BXGD013145	Cerebral artery stenosis
C1536220	BXGD013341	ST segment elevation myocardial infarction	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1704436	BXGD013564	Peripheral Arterial Diseases	Cardiovascular Diseases
C1840253	BXGD014438	IgE RESPONSIVENESS, ATOPIC	Respiratory Tract Diseases; Immune System Diseases
C1845050	BXGD014703	PIGMENTARY DISORDER, RETICULATE, WITH SYSTEMIC MANIFESTATIONS	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C1862596	BXGD016135	Familial hypobetalipoproteinemia	Nutritional and Metabolic Diseases
C1956346	BXGD016627	Coronary Artery Disease	Cardiovascular Diseases
C2242539	BXGD016977	Subcutaneous infection
C2607914	BXGD017148	Allergic rhinitis (disorder)	Respiratory Tract Diseases; Immune System Diseases; Otorhinolaryngologic Diseases
C2733158	BXGD017562	Cerebral Small Vessel Diseases	Nervous System Diseases; Cardiovascular Diseases
C2931822	BXGD018068	Nasopharyngeal carcinoma	Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C2939419	BXGD018178	Secondary Neoplasm	Pathological Conditions, Signs and Symptoms; Neoplasms
C3266262	BXGD018600	Multiple Chronic Conditions	Pathological Conditions, Signs and Symptoms
C3280315	BXGD018822	Platelet-Activating Factor Acetylhydrolase Deficiency	Respiratory Tract Diseases; Immune System Diseases
C3711850	BXGD019400	Opticospinal Multiple Sclerosis	Immune System Diseases; Nervous System Diseases
C4016754	BXGD020371	ASTHMA AND ATOPY, SUSCEPTIBILITY TO
C4073143	BXGD022047	Increased level of platelet-activating factor
C4255010	BXGD022310	Non-ST Elevated Myocardial Infarction	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C4304667	BXGD022582	Benign concentric annular macular dystrophy
C4551472	BXGD023303	Hypertrophic obstructive cardiomyopathy	Cardiovascular Diseases
C4699152	BXGD023634	ST-segment elevation myocardial infarction (STEMI)
C4699508	BXGD023637	Cardioembolism (high-risk/medium-risk)
C4699512	BXGD023639	Large-artery atherosclerosis (embolus/thrombosis)
C4700045	BXGD023640	Non-ST-segment elevation myocardial infarction (NSTEMI)
C4703473	BXGD023650	Atherosclerotic lesion	Cardiovascular Diseases

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0000368	Gallic acid		170.12
BXGC0000441	Dimethyl sulfoxide		78.13
BXGC0000505	Protocatechuic acid		154.12
BXGC0001857	Caffeic acid		180.16
BXGC0001879	Chlorogenic acid		354.31
BXGC0001889	p-Coumaric acid		164.16
BXGC0002586	Calcium		40.08
BXGC0002588	Magnesium		24.31
BXGC0002690	alpha-Catechin		290.27
BXGC0003705	Chloride		35.45
BXGC0004747	trans-Sinapic acid		224.21
BXGC0006366	trans-Ferulic acid		194.18
BXGC0006368	Formic acid		46.03
BXGC0010351	Caftaric acid		312.23
BXGC0042127	Oxyquinoline		145.05
BXGC0048313	Rosmarinic Acid		360.08
BXGC0048389	Catechin		290.08
BXGC0049447	acetate		59.01

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}