Showing entry for Acetyl-CoA acetyltransferase, mitochondrial


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008993
Protein NameAcetyl-CoA acetyltransferase, mitochondrial
Uniport IdP24752
GeneACAT1
Gene Id38
DomainThiolase_C; Thiolase_N
Pfam PF02803   PF00108  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00071 Fatty acid degradation
1. Metabolism 1.3 Lipid metabolism hsa00072 Synthesis and degradation of ketone bodies
1. Metabolism 1.5 Amino acid metabolism hsa00280 Valine, leucine and isoleucine degradation
1. Metabolism 1.5 Amino acid metabolism hsa00310 Lysine degradation
1. Metabolism 1.5 Amino acid metabolism hsa00380 Tryptophan metabolism
1. Metabolism 1.1 Carbohydrate metabolism hsa00620 Pyruvate metabolism
1. Metabolism 1.1 Carbohydrate metabolism hsa00630 Glyoxylate and dicarboxylate metabolism
1. Metabolism 1.1 Carbohydrate metabolism hsa00640 Propanoate metabolism
1. Metabolism 1.1 Carbohydrate metabolism hsa00650 Butanoate metabolism
1. Metabolism 1.9 Metabolism of terpenoids and polyketides hsa00900 Terpenoid backbone biosynthesis
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
1. Metabolism 1.0 Global and overview maps hsa01200 Carbon metabolism
1. Metabolism 1.0 Global and overview maps hsa01212 Fatty acid metabolism
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006085 acetyl-CoA biosynthetic process
Biological Process GO:0046356 acetyl-CoA catabolic process
Biological Process GO:0060612 adipose tissue development
Biological Process GO:0007420 brain development
Biological Process GO:0009083 branched-chain amino acid catabolic process
Biological Process GO:0034435 cholesterol esterification
Biological Process GO:0015937 coenzyme A biosynthetic process
Biological Process GO:0015936 coenzyme A metabolic process
Biological Process GO:0006635 fatty acid beta-oxidation
Biological Process GO:0006550 isoleucine catabolic process
Biological Process GO:0046951 ketone body biosynthetic process
Biological Process GO:0046952 ketone body catabolic process
Biological Process GO:1902224 ketone body metabolic process
Biological Process GO:0001889 liver development
Biological Process GO:0072229 metanephric proximal convoluted tubule development
Biological Process GO:1902860 propionyl-CoA biosynthetic process
Biological Process GO:0009725 response to hormone
Biological Process GO:0014070 response to organic cyclic compound
Biological Process GO:0042594 response to starvation
molecular function GO:0003985 acetyl-CoA C-acetyltransferase activity
molecular function GO:0003988 acetyl-CoA C-acyltransferase activity
molecular function GO:0016453 C-acetyltransferase activity
molecular function GO:0019899 enzyme binding
molecular function GO:0042802 identical protein binding
molecular function GO:0030955 potassium ion binding
cellular component GO:0070062 extracellular exosome
cellular component GO:0005759 mitochondrial matrix
cellular component GO:0005739 mitochondrion
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-70895 Branched-chain amino acid catabolism
R-HSA-71291 Metabolism of amino acids and derivatives
R-HSA-74182 Ketone body metabolism
R-HSA-77108 Utilization of Ketone Bodies
R-HSA-77111 Synthesis of Ketone Bodies
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002170 BXGD000105 Alopecia Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0003123 BXGD000178 Anorexia Pathological Conditions, Signs and Symptoms
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004135 BXGD000257 Ataxia Telangiectasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007113 BXGD000430 Rectal Carcinoma Digestive System Diseases; Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009421 BXGD000608 Comatose Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010200 BXGD000653 Coughing Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0010481 BXGD000673 Cushing Syndrome Endocrine System Diseases
C0011175 BXGD000701 Dehydration Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013238 BXGD000806 Dry Eye Syndromes Eye Diseases
C0013604 BXGD000859 Edema Pathological Conditions, Signs and Symptoms
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0018553 BXGD001203 Hamartoma Syndrome, Multiple Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms
C0018965 BXGD001258 Hematuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020615 BXGD001445 Hypoglycemia Nutritional and Metabolic Diseases
C0020649 BXGD001459 Hypotension Cardiovascular Diseases
C0021125 BXGD001483 Impulsive Behavior Behavior and Behavior Mechanisms
C0022333 BXGD001534 Jacksonian Seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0022638 BXGD001567 Ketosis Nutritional and Metabolic Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023364 BXGD001638 Leptospirosis Infections
C0023518 BXGD001677 Leukocytosis Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0025521 BXGD001876 Inborn Errors of Metabolism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0026106 BXGD001889 Mild Mental Retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027726 BXGD002030 Nephrotic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030232 BXGD002197 Pallor Pathological Conditions, Signs and Symptoms
C0032927 BXGD002381 Precancerous Conditions Neoplasms
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0036857 BXGD002638 Severe intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0039538 BXGD002819 Teratoma Neoplasms
C0042963 BXGD003018 Vomiting Pathological Conditions, Signs and Symptoms
C0043325 BXGD003041 Xanthomatosis Nutritional and Metabolic Diseases
C0085595 BXGD003198 Body odor
C0085631 BXGD003214 Agitation Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0085632 BXGD003215 Apathy Behavior and Behavior Mechanisms
C0149721 BXGD003349 Left Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0149958 BXGD003395 Complex partial seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151888 BXGD003497 Hyporeflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0153567 BXGD003665 Uterine Cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0154251 BXGD003710 Lipid Metabolism Disorders Nutritional and Metabolic Diseases
C0162275 BXGD003924 Ketonuria Nutritional and Metabolic Diseases
C0162429 BXGD003942 Malnutrition Nutritional and Metabolic Diseases
C0206686 BXGD004241 Adrenocortical carcinoma Neoplasms; Endocrine System Diseases
C0220981 BXGD004348 Metabolic acidosis Nutritional and Metabolic Diseases
C0220982 BXGD004349 Ketoacidosis Nutritional and Metabolic Diseases
C0220994 BXGD004357 Hyperammonemia Pathological Conditions, Signs and Symptoms
C0221032 BXGD004374 Familial generalized lipodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0231835 BXGD004527 Tachypnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0234533 BXGD004687 Generalized seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234535 BXGD004688 Clonic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0237123 BXGD004845 Alcohol or Other Drugs use
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0243038 BXGD005211 Carcinoma, Lewis Lung Neoplasms
C0268490 BXGD005962 Tyrosinemia, Type I Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0268621 BXGD006012 Hepatic methionine adenosyltransferase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0270824 BXGD006113 Visual seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270844 BXGD006115 Tonic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270846 BXGD006116 Epileptic drop attack Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0278061 BXGD006492 Abnormal mental state Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0278488 BXGD006515 Carcinoma breast stage IV
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279606 BXGD006647 Childhood Hepatocellular Carcinoma Digestive System Diseases; Neoplasms
C0279607 BXGD006648 Adult Hepatocellular Carcinoma Digestive System Diseases; Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0314719 BXGD006890 Dryness of eye Eye Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0342443 BXGD007481 Adrenal Cushing's syndrome Endocrine System Diseases
C0342869 BXGD007568 Deficiency of acetyl-CoA acyltransferase (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0343804 BXGD007648 Chronic Chagas' disease Infections
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0422850 BXGD008457 Seizures, Somatosensory Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422852 BXGD008458 Seizures, Auditory Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422853 BXGD008459 Olfactory seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422854 BXGD008460 Gustatory seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422855 BXGD008461 Vertiginous seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0494475 BXGD009030 Tonic - clonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0520947 BXGD009126 Clumsiness - motor delay Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0521654 BXGD009156 Neurologic Deficits Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0694563 BXGD009854 Excessive daytime somnolence
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0740394 BXGD009989 Hyperuricemia Pathological Conditions, Signs and Symptoms
C0751056 BXGD010306 Non-epileptic convulsion Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751110 BXGD010318 Single Seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751123 BXGD010326 Atonic Absence Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751494 BXGD010472 Convulsive Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751495 BXGD010473 Seizures, Focal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751496 BXGD010474 Seizures, Sensory Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0836924 BXGD010864 Thrombocytosis Hemic and Lymphatic Diseases
C1262477 BXGD011882 Weight decreased Pathological Conditions, Signs and Symptoms
C1266042 BXGD011938 Chromophobe Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1285498 BXGD012171 Vegetation
C1304249 BXGD012332 Cutaneous xanthoma
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1512981 BXGD013196 Mammary Tumorigenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1535939 BXGD013323 Pneumocystis jiroveci pneumonia Infections; Respiratory Tract Diseases
C1536500 BXGD013345 Deficiency of acetyl-CoA acetyltransferase Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C1611743 BXGD013456 Familial (FPAH)
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1836440 BXGD014115 Increased serum lactate Nutritional and Metabolic Diseases
C1848528 BXGD014934 Extrapyramidal dyskinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1854301 BXGD015391 Motor delay Mental Disorders
C1859860 BXGD015937 Episodic ketoacidosis
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1963060 BXGD016679 Agitation, CTCAE 3.0
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2931852 BXGD018079 Clear-cell metastatic renal cell carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2938940 BXGD018168 Post stroke depression Mental Disorders
C3241937 BXGD018578 Nonalcoholic Steatohepatitis Digestive System Diseases
C3495874 BXGD019008 Nonepileptic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3665983 BXGD019314 Oral aversion
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4022764 BXGD020991 Abnormal metabolic brain imaging by MRS
C4048158 BXGD021890 Convulsions Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4048705 BXGD021907 Hypermethioninemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4316903 BXGD022711 Absence Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4317109 BXGD022725 Epileptic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4317123 BXGD022727 Myoclonic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4324621 BXGD022774 Opioid use disorder
C4505436 BXGD022962 Generalized Absence Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4529962 BXGD023178 Fatty Liver Disease
C4552855 BXGD023528 Agitation, CTCAE 5.0
C4553743 BXGD023548 Spasticity, CTCAE
C4554061 BXGD023558 Body Odor, CTCAE
C4703473 BXGD023650 Atherosclerotic lesion Cardiovascular Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002591 Potassium 39.1
BXGC0003705 Chloride 35.45
BXGC0040150 Cannabidiol 314.22
BXGC0045683 huperzine A 242.14
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein