Showing entry for NT-3 growth factor receptor


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013625
Protein NameNT-3 growth factor receptor
Uniport IdQ16288
GeneNTRK3
Gene Id4916
DomainI-set; ig; LRRNT; LRR_8; Pkinase_Tyr; TPKR_C2
Pfam PF07679   PF00047   PF13855   PF01462   PF07714   PF16920  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.6 Nervous system hsa04722 Neurotrophin signaling pathway
6. Human Diseases 6.1 Cancers: Overview hsa05230 Central carbon metabolism in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0090630 activation of GTPase activity
Biological Process GO:0000187 activation of MAPK activity
Biological Process GO:0032148 activation of protein kinase B activity
Biological Process GO:1990090 cellular response to nerve growth factor stimulus
Biological Process GO:0071300 cellular response to retinoic acid
Biological Process GO:0007623 circadian rhythm
Biological Process GO:0090102 cochlea development
Biological Process GO:0007507 heart development
Biological Process GO:0070306 lens fiber cell differentiation
Biological Process GO:0042490 mechanoreceptor differentiation
Biological Process GO:0019056 modulation by virus of host transcription
Biological Process GO:0007275 multicellular organism development
Biological Process GO:0022011 myelination in peripheral nervous system
Biological Process GO:0048712 negative regulation of astrocyte differentiation
Biological Process GO:0060548 negative regulation of cell death
Biological Process GO:0001933 negative regulation of protein phosphorylation
Biological Process GO:0007399 nervous system development
Biological Process GO:0019227 neuronal action potential propagation
Biological Process GO:0048665 neuron fate specification
Biological Process GO:0001764 neuron migration
Biological Process GO:2000251 positive regulation of actin cytoskeleton reorganization
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0048691 positive regulation of axon extension involved in regeneration
Biological Process GO:0030335 positive regulation of cell migration
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0033674 positive regulation of kinase activity
Biological Process GO:0043410 positive regulation of MAPK cascade
Biological Process GO:0010976 positive regulation of neuron projection development
Biological Process GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway
Biological Process GO:0033138 positive regulation of peptidyl-serine phosphorylation
Biological Process GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
Biological Process GO:0010863 positive regulation of phospholipase C activity
Biological Process GO:0050927 positive regulation of positive chemotaxis
Biological Process GO:0001934 positive regulation of protein phosphorylation
Biological Process GO:0051965 positive regulation of synapse assembly
Biological Process GO:0043408 regulation of MAPK cascade
Biological Process GO:0099151 regulation of postsynaptic density assembly
Biological Process GO:0051896 regulation of protein kinase B signaling
Biological Process GO:0048678 response to axon injury
Biological Process GO:0051412 response to corticosterone
Biological Process GO:0045471 response to ethanol
Biological Process GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
molecular function GO:0005524 ATP binding
molecular function GO:0005004 GPI-linked ephrin receptor activity
molecular function GO:0043121 neurotrophin binding
molecular function GO:0005030 neurotrophin receptor activity
molecular function GO:0002039 p53 binding
molecular function GO:0004714 transmembrane receptor protein tyrosine kinase activity
cellular component GO:0030424 axon
cellular component GO:0005737 cytoplasm
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0099055 integral component of postsynaptic membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0043235 receptor complex
Reactome
Pathway Id Pathway Name
R-HSA-112316 Neuronal System
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-166520 Signaling by NTRKs
R-HSA-166520 Signaling by NTRKs
R-HSA-388844 Receptor-type tyrosine-protein phosphatases
R-HSA-6794362 Protein-protein interactions at synapses
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9034013 NTF3 activates NTRK3 signaling
R-HSA-9034013 NTF3 activates NTRK3 signaling
R-HSA-9034015 Signaling by NTRK3 (TRKC)
R-HSA-9034015 Signaling by NTRK3 (TRKC)
R-HSA-9034793 Activated NTRK3 signals through PLCG1
R-HSA-9034793 Activated NTRK3 signals through PLCG1
R-HSA-9034864 Activated NTRK3 signals through RAS
R-HSA-9603381 Activated NTRK3 signals through PI3K
R-HSA-9603381 Activated NTRK3 signals through PI3K
R-HSA-9603505 NTRK3 as a dependence receptor
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0003123 BXGD000178 Anorexia Pathological Conditions, Signs and Symptoms
C0003125 BXGD000179 Anorexia Nervosa Mental Disorders
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010606 BXGD000677 Adenoid Cystic Carcinoma Neoplasms
C0010631 BXGD000678 Cystadenocarcinoma Neoplasms
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013473 BXGD000845 Eating Disorders Mental Disorders
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0015674 BXGD001012 Chronic Fatigue Syndrome Infections; Musculoskeletal Diseases; Nervous System Diseases
C0016057 BXGD001042 Fibrosarcoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0018798 BXGD001223 Congenital Heart Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018818 BXGD001236 Ventricular Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0019569 BXGD001337 Hirschsprung Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0019621 BXGD001340 Histiocytosis, Langerhans-Cell Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C0021704 BXGD001510 Intelligence Behavior and Behavior Mechanisms
C0022665 BXGD001573 Kidney Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0026277 BXGD001899 Mixed Salivary Gland Tumor Neoplasms
C0026998 BXGD001959 Acute Myeloid Leukemia, M1 Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0027831 BXGD002047 Neurofibromatosis 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0028768 BXGD002084 Obsessive-Compulsive Disorder Mental Disorders
C0030297 BXGD002204 Pancreatic Neoplasm Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0030319 BXGD002208 Panic Disorder Mental Disorders
C0036095 BXGD002576 Salivary Gland Neoplasms Neoplasms; Stomatognathic Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0037286 BXGD002681 Skin Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C0037579 BXGD002694 Soft Tissue Neoplasms Neoplasms
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039685 BXGD002825 Tetralogy of Fallot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0042995 BXGD003020 Vulvar Neoplasms Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0085758 BXGD003250 Aganglionosis, Colonic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0151468 BXGD003424 Thyroid Gland Follicular Adenoma Neoplasms; Endocrine System Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0152021 BXGD003520 Congenital heart disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0153690 BXGD003684 Secondary malignant neoplasm of bone Pathological Conditions, Signs and Symptoms; Neoplasms; Musculoskeletal Diseases
C0162678 BXGD003974 Neurofibromatoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0205647 BXGD004099 Follicular adenoma Neoplasms
C0205945 BXGD004142 Sarcoma, Spindle Cell Neoplasms
C0206628 BXGD004193 Mesoblastic Nephroma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0206647 BXGD004212 Dermatofibrosarcoma Neoplasms
C0206648 BXGD004213 Myofibromatosis Neoplasms
C0206681 BXGD004236 Adenocarcinoma, Clear Cell Neoplasms
C0206685 BXGD004240 Acinar Cell Carcinoma Neoplasms
C0206692 BXGD004243 Carcinoma, Lobular Neoplasms; Skin and Connective Tissue Diseases
C0206694 BXGD004245 Mucoepidermoid Carcinoma Neoplasms
C0206695 BXGD004246 Carcinoma, Neuroendocrine Neoplasms
C0220636 BXGD004304 Malignant neoplasm of salivary gland Neoplasms; Stomatognathic Diseases
C0238198 BXGD004893 Gastrointestinal Stromal Tumors Digestive System Diseases; Neoplasms
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0259783 BXGD005221 mixed gliomas Neoplasms
C0269102 BXGD006053 Endometrioma Female Urogenital Diseases and Pregnancy Complications
C0270823 BXGD006112 Petit mal status Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0278488 BXGD006515 Carcinoma breast stage IV
C0278510 BXGD006526 Childhood Medulloblastoma Neoplasms
C0278595 BXGD006545 Adult Fibrosarcoma Neoplasms
C0278701 BXGD006566 Gastric Adenocarcinoma Digestive System Diseases; Neoplasms
C0278876 BXGD006607 Adult Medulloblastoma Neoplasms
C0279565 BXGD006638 Invasive Lobular Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0279737 BXGD006689 low-grade salivary gland carcinoma
C0280100 BXGD006713 Solid Neoplasm Neoplasms
C0311335 BXGD006877 Grand Mal Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0334121 BXGD006996 Inflammatory Myofibroblastic Tumor Pathological Conditions, Signs and Symptoms
C0334371 BXGD007049 Secretory breast carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0334431 BXGD007066 Melanocytoma
C0334459 BXGD007074 Infantile fibrosarcoma Neoplasms
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0345958 BXGD007751 Large cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0392784 BXGD008069 Dermatofibrosarcoma Protuberans Neoplasms
C0393734 BXGD008131 Complex Partial Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0424101 BXGD008519 Inattention
C0424290 BXGD008523 Compulsive hoarding Behavior and Behavior Mechanisms
C0432409 BXGD008786 Trisomy 11 Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0442874 BXGD008814 Neuropathy Nervous System Diseases
C0474967 BXGD008965 Spindle cell nevus of Reed Neoplasms
C0496892 BXGD009045 Benign neoplasm of kidney Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0522631 BXGD009205 Acute myeloid leukemia, minimal differentiation Neoplasms
C0525045 BXGD009255 Mood Disorders Mental Disorders
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0553580 BXGD009399 Ewings sarcoma Neoplasms
C0555198 BXGD009432 Malignant Glioma Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0751522 BXGD010488 Status Epilepticus, Subclinical Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751523 BXGD010489 Non-Convulsive Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751524 BXGD010490 Simple Partial Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0879615 BXGD011394 Stromal Neoplasm Neoplasms
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1176475 BXGD011798 Ductal Carcinoma Neoplasms
C1261473 BXGD011855 Sarcoma Neoplasms
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1266119 BXGD011964 Solitary fibrous tumor Neoplasms
C1266124 BXGD011967 tumor miofibroblástico peribronquial congénito
C1266127 BXGD011968 Histiocytoma, Angiomatoid Fibrous Neoplasms
C1266144 BXGD011976 Pleuropulmonary blastoma Neoplasms
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1320471 BXGD012424 Mesoblastic nephroma, cellular Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1332965 BXGD012565 Congenital Mesoblastic Nephroma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1516474 BXGD013213 Cellular Congenital Mesoblastic Nephroma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1704228 BXGD013532 Thyroid Gland Adenocarcinoma Neoplasms; Endocrine System Diseases
C1879321 BXGD016572 Acute Myeloid Leukemia (AML-M2) Neoplasms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2985280 BXGD018223 Blood Protein Measurement
C3489630 BXGD018939 Somatotrophinoma, Familial Neoplasms; Nervous System Diseases; Endocrine System Diseases
C3693482 BXGD019337 Giant Cell Fibroblastoma Neoplasms
C3899655 BXGD020091 Childhood Langerhans Cell Histiocytosis Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C3900100 BXGD020108 Adult Langerhans Cell Histiocytosis Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C4042906 BXGD021883 Mammary Analogue Secretory Carcinoma Neoplasms
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4330658 BXGD022803 Mammary Analog Secretory Carcinoma of Salivary Gland
C4551686 BXGD023391 Malignant neoplasm of soft tissue Neoplasms
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722099 BXGD023789 High grade glioma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0003705 Chloride 35.45
BXGC0020368 Gambogic Acid 628.3
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein