Showing entry for Serine/threonine-protein kinase SIK1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011210
Protein NameSerine/threonine-protein kinase SIK1
Uniport IdP57059
GeneSIK1
Gene Id102724428;150094
DomainPkinase
Pfam PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.2 Endocrine system hsa04922 Glucagon signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04922 Glucagon signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0055007 cardiac muscle cell differentiation
Biological Process GO:0007049 cell cycle
Biological Process GO:0043153 entrainment of circadian clock by photoperiod
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0032792 negative regulation of CREB transcription factor activity
Biological Process GO:0045721 negative regulation of gluconeogenesis
Biological Process GO:0010868 negative regulation of triglyceride biosynthetic process
Biological Process GO:2000210 positive regulation of anoikis
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0045595 regulation of cell differentiation
Biological Process GO:0007346 regulation of mitotic cell cycle
Biological Process GO:0010830 regulation of myotube differentiation
Biological Process GO:0002028 regulation of sodium ion transport
Biological Process GO:0048511 rhythmic process
molecular function GO:0071889 14-3-3 protein binding
molecular function GO:0005524 ATP binding
molecular function GO:0008140 cAMP response element binding protein binding
molecular function GO:0000287 magnesium ion binding
molecular function GO:0019901 protein kinase binding
molecular function GO:0004674 protein serine/threonine kinase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-400253 Circadian Clock
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000737 BXGD000005 Abdominal Pain Pathological Conditions, Signs and Symptoms
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007193 BXGD000451 Cardiomyopathy, Dilated Cardiovascular Diseases
C0008925 BXGD000575 Cleft Palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009952 BXGD000639 Febrile Convulsions Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0010200 BXGD000653 Coughing Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0010701 BXGD000688 Phyllodes Tumor Neoplasms
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013384 BXGD000826 Dyskinetic syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0014474 BXGD000917 Ependymoma Neoplasms
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0018818 BXGD001236 Ventricular Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023380 BXGD001640 Lethargy Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023531 BXGD001684 Leukoplakia Pathological Conditions, Signs and Symptoms; Neoplasms
C0023532 BXGD001685 Leukoplakia, Oral Pathological Conditions, Signs and Symptoms; Neoplasms; Stomatognathic Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025281 BXGD001848 Meniere Disease Otorhinolaryngologic Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027066 BXGD001966 Myoclonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0034013 BXGD002450 Precocious Puberty Endocrine System Diseases
C0035127 BXGD002510 Cumulative Trauma Disorders Wounds and Injuries
C0037317 BXGD002689 Sleep disturbances Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0037579 BXGD002694 Soft Tissue Neoplasms Neoplasms
C0037769 BXGD002701 West Syndrome Nervous System Diseases
C0038271 BXGD002742 Stereotyped Behavior Behavior and Behavior Mechanisms
C0038273 BXGD002743 Stereotypic Movement Disorder Mental Disorders
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0039103 BXGD002791 Synovitis Musculoskeletal Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0041960 BXGD002943 Ureterocele Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0085271 BXGD003148 Self-Injurious Behavior Behavior and Behavior Mechanisms
C0085583 BXGD003194 Choreoathetosis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0085584 BXGD003195 Encephalopathies Nervous System Diseases
C0087031 BXGD003319 Juvenile-Onset Still Disease Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0220650 BXGD004310 Metastatic malignant neoplasm to brain Pathological Conditions, Signs and Symptoms; Neoplasms; Nervous System Diseases
C0232466 BXGD004543 Feeding difficulties
C0235831 BXGD004773 Renal Cell Dysplasia Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238461 BXGD004936 Anaplastic thyroid carcinoma Neoplasms
C0239594 BXGD004987 Short finger
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0266483 BXGD005680 Pachygyria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0270846 BXGD006116 Epileptic drop attack Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270855 BXGD006121 Early myoclonic encephalopathy Nervous System Diseases
C0278874 BXGD006605 Adult Ependymoma Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0278883 BXGD006614 Metastatic melanoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0338106 BXGD007167 Adenocarcinoma of colon Digestive System Diseases; Neoplasms
C0344482 BXGD007678 Hypoplasia of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0393706 BXGD008126 Early infantile epileptic encephalopathy with suppression bursts Nervous System Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0409959 BXGD008400 Osteoarthritis, Knee Musculoskeletal Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0476273 BXGD008986 Respiratory distress Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0494475 BXGD009030 Tonic - clonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0543888 BXGD009300 Epileptic encephalopathy Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598275 BXGD009664 Diffuse cerebral atrophy Nervous System Diseases; Mental Disorders
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0684276 BXGD009793 Hypsarrhythmia Nervous System Diseases
C0700201 BXGD009880 Dyssomnias Nervous System Diseases; Mental Disorders
C0740279 BXGD009973 Cerebellar atrophy
C0752324 BXGD010717 Focal Tonic Seizures Nervous System Diseases
C0796611 BXGD010835 Newly Diagnosed Childhood Ependymoma Neoplasms
C0851578 BXGD010925 Sleep Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0856975 BXGD011127 Autistic behavior Behavior and Behavior Mechanisms
C1261473 BXGD011855 Sarcoma Neoplasms
C1265996 BXGD011927 Large cell neuroendocrine carcinoma Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1277241 BXGD012110 Delayed myelination Mental Disorders
C1301194 BXGD012284 Salivary duct carcinoma Neoplasms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1306503 BXGD012363 Congenital exomphalos Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1387005 BXGD012953 Penis agenesis Male Urogenital Diseases
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1527304 BXGD013266 Allergic Reaction Immune System Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1708550 BXGD013604 Intimal sarcoma Neoplasms
C1720189 BXGD013668 Episodic Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1836038 BXGD014073 Poor head control Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1836508 BXGD014124 Generalized tonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1836542 BXGD014129 Depressed nasal bridge
C1836830 BXGD014165 Developmental regression Mental Disorders
C1837142 BXGD014201 Poor suck
C1840077 BXGD014434 Anteverted nostril
C1844548 BXGD014642 Hypoplastic finger
C1844906 BXGD014692 Broad finger
C1851584 BXGD015221 Childhood Ependymoma Neoplasms
C1854882 BXGD015439 Absent speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1857679 BXGD015735 Sloping forehead
C1860834 BXGD016006 Infantile muscular hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1969156 BXGD016761 EEG with burst suppression
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2853920 BXGD017809 Lymphoblastic T-cell lymphoma
C3463992 BXGD018904 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 1 Nervous System Diseases
C3495559 BXGD018994 Juvenile arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3536714 BXGD019069 Renal dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3714758 BXGD019431 Juvenile psoriatic arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3806482 BXGD019514 Recurrent respiratory infections Infections; Respiratory Tract Diseases
C3887898 BXGD019926 Infantile Spasm Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4021759 BXGD020762 Generalized myoclonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4022739 BXGD020975 Abnormal neuron morphology
C4022849 BXGD021012 Absent thumbnail
C4023484 BXGD021201 Uni- and bilateral multifocal epileptiform discharges
C4023499 BXGD021204 Generalized clonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4023528 BXGD021211 Abnormality of skin morphology Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C4023683 BXGD021240 EEG with spike-wave complexes
C4023986 BXGD021282 Broad phalanx of the toes
C4024923 BXGD021476 Diffuse white matter abnormalities Pathological Conditions, Signs and Symptoms
C4049830 BXGD021953 Focal seizures, afebril Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4225360 BXGD022238 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 30
C4316903 BXGD022711 Absence Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4551686 BXGD023391 Malignant neoplasm of soft tissue Neoplasms
C4551850 BXGD023418 Eyelid myoclonias
C4552072 BXGD023482 X-linked infantile spasms Nervous System Diseases
C4552091 BXGD023485 Polyarthritis, Juvenile, Rheumatoid Factor Negative Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C4553743 BXGD023548 Spasticity, CTCAE
C4704862 BXGD023681 Polyarthritis, Juvenile, Rheumatoid Factor Positive Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0012352 Chelerythrine 348.12
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein