Showing entry for Neurexin-1-beta


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011235
Protein NameNeurexin-1-beta
Uniport IdP58400
GeneNRXN1
Gene Id9378
DomainLaminin_G_2; Syndecan
Pfam PF02210   PF01034  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04514 Cell adhesion molecules (CAMs)
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030534 adult behavior
Biological Process GO:0001525 angiogenesis
Biological Process GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
Biological Process GO:0071277 cellular response to calcium ion
Biological Process GO:0021707 cerebellar granule cell differentiation
Biological Process GO:0045184 establishment of protein localization
Biological Process GO:0097112 gamma-aminobutyric acid receptor clustering
Biological Process GO:0097116 gephyrin clustering involved in postsynaptic density assembly
Biological Process GO:0097117 guanylate kinase-associated protein clustering
Biological Process GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
Biological Process GO:0007612 learning
Biological Process GO:0051490 negative regulation of filopodium assembly
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly
Biological Process GO:0023041 neuronal signal transduction
Biological Process GO:0007158 neuron cell-cell adhesion
Biological Process GO:0031175 neuron projection development
Biological Process GO:0097114 NMDA glutamate receptor clustering
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:2000463 positive regulation of excitatory postsynaptic potential
Biological Process GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0033138 positive regulation of peptidyl-serine phosphorylation
Biological Process GO:1905520 positive regulation of presynaptic active zone assembly
Biological Process GO:0010739 positive regulation of protein kinase A signaling
Biological Process GO:0051897 positive regulation of protein kinase B signaling
Biological Process GO:1900020 positive regulation of protein kinase C activity
Biological Process GO:1903078 positive regulation of protein localization to plasma membrane
Biological Process GO:0051965 positive regulation of synapse assembly
Biological Process GO:0051968 positive regulation of synaptic transmission, glutamatergic
Biological Process GO:0097119 postsynaptic density protein 95 clustering
Biological Process GO:0097104 postsynaptic membrane assembly
Biological Process GO:0097105 presynaptic membrane assembly
Biological Process GO:0090126 protein-containing complex assembly involved in synapse maturation
Biological Process GO:0035418 protein localization to synapse
Biological Process GO:0097120 receptor localization to synapse
Biological Process GO:2000311 regulation of AMPA receptor activity
Biological Process GO:2000310 regulation of NMDA receptor activity
Biological Process GO:0007165 signal transduction
Biological Process GO:0035176 social behavior
Biological Process GO:0007416 synapse assembly
Biological Process GO:0097091 synaptic vesicle clustering
Biological Process GO:0071625 vocalization behavior
molecular function GO:0048306 calcium-dependent protein binding
molecular function GO:0050839 cell adhesion molecule binding
molecular function GO:0046872 metal ion binding
molecular function GO:0097109 neuroligin family protein binding
molecular function GO:0005102 signaling receptor binding
molecular function GO:0004888 transmembrane signaling receptor activity
molecular function GO:0005105 type 1 fibroblast growth factor receptor binding
cellular component GO:0044295 axonal growth cone
cellular component GO:0009986 cell surface
cellular component GO:0030139 endocytic vesicle
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0099056 integral component of presynaptic membrane
cellular component GO:0043025 neuronal cell body
cellular component GO:0031965 nuclear membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0098793 presynapse
cellular component GO:0042734 presynaptic membrane
cellular component GO:0031982 vesicle
Reactome
Pathway Id Pathway Name
R-HSA-112316 Neuronal System
R-HSA-112316 Neuronal System
R-HSA-6794361 Neurexins and neuroligins
R-HSA-6794361 Neurexins and neuroligins
R-HSA-6794362 Protein-protein interactions at synapses
R-HSA-6794362 Protein-protein interactions at synapses
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0000772 BXGD000009 Multiple congenital anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0001807 BXGD000077 Aggressive behavior Behavior and Behavior Mechanisms
C0001925 BXGD000090 Albuminuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0001948 BXGD000091 Alcohol consumption Behavior and Behavior Mechanisms
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0004936 BXGD000295 Mental disorders Mental Disorders
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0006111 BXGD000369 Brain Diseases Nervous System Diseases
C0006325 BXGD000393 Bruxism Stomatognathic Diseases
C0007570 BXGD000467 Celiac Disease Digestive System Diseases; Nutritional and Metabolic Diseases
C0007787 BXGD000487 Transient Ischemic Attack Nervous System Diseases; Cardiovascular Diseases
C0008073 BXGD000518 Developmental Disabilities Mental Disorders
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013132 BXGD000799 Drooling Stomatognathic Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0016667 BXGD001072 Fragile X Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0017168 BXGD001101 Gastroesophageal reflux disease Digestive System Diseases
C0018818 BXGD001236 Ventricular Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0020578 BXGD001434 Hyperventilation Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0020796 BXGD001468 Profound Mental Retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0021704 BXGD001510 Intelligence Behavior and Behavior Mechanisms
C0023012 BXGD001599 Language Delay Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0023014 BXGD001600 Language Development Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023980 BXGD001725 Longevity
C0024433 BXGD001771 Macrostomia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0025362 BXGD001866 Mental Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0025363 BXGD001867 Mental Retardation, Psychosocial Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027404 BXGD001984 Narcolepsy Nervous System Diseases; Mental Disorders
C0028043 BXGD002066 Nicotine Dependence Chemically-Induced Disorders; Mental Disorders
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0034013 BXGD002450 Precocious Puberty Endocrine System Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036857 BXGD002638 Severe intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0037369 BXGD002691 Smoking Behavior and Behavior Mechanisms
C0038271 BXGD002742 Stereotyped Behavior Behavior and Behavior Mechanisms
C0038273 BXGD002743 Stereotypic Movement Disorder Mental Disorders
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0039474 BXGD002812 Temperament Behavior and Behavior Mechanisms
C0040517 BXGD002872 Gilles de la Tourette syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0040961 BXGD002891 Tricuspid Valve Insufficiency Cardiovascular Diseases
C0085271 BXGD003148 Self-Injurious Behavior Behavior and Behavior Mechanisms
C0150080 BXGD003402 Social Communication Disorder Mental Disorders
C0151888 BXGD003497 Hyporeflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0221354 BXGD004446 Frontal bossing Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0221356 BXGD004448 Brachycephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0232466 BXGD004543 Feeding difficulties
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0236664 BXGD004818 Alcohol-Related Disorders Chemically-Induced Disorders; Mental Disorders
C0236792 BXGD004830 Asperger Syndrome Mental Disorders
C0236970 BXGD004843 Alcohol-Induced Disorders Chemically-Induced Disorders
C0239154 BXGD004967 High pitched cry Behavior and Behavior Mechanisms
C0241210 BXGD005086 Speech Delay Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0241442 BXGD005099 Protrusion of tongue
C0265354 BXGD005529 CHARGE Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0265529 BXGD005542 Plagiocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0266815 BXGD005717 Cow milk allergy Digestive System Diseases; Immune System Diseases
C0270850 BXGD006117 Idiopathic generalized epilepsy Nervous System Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0349204 BXGD007892 Nonorganic psychosis Mental Disorders
C0376634 BXGD008006 Craniofacial Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0399526 BXGD008251 Class III malocclusion Stomatognathic Diseases
C0401149 BXGD008273 Chronic constipation Pathological Conditions, Signs and Symptoms
C0410702 BXGD008447 Adolescent idiopathic scoliosis Musculoskeletal Diseases
C0423113 BXGD008473 Telecanthus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0424503 BXGD008532 Dysmorphic facies
C0424605 BXGD008535 Developmental delay (disorder) Mental Disorders
C0432072 BXGD008718 Dysmorphic features
C0454651 BXGD008851 Specific language impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0454655 BXGD008852 Semantic-Pragmatic Disorder Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0494463 BXGD009029 Alzheimer Disease, Late Onset Nervous System Diseases; Mental Disorders
C0524528 BXGD009229 Pervasive Development Disorder Mental Disorders
C0543888 BXGD009300 Epileptic encephalopathy Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0596887 BXGD009648 mathematical ability
C0684276 BXGD009793 Hypsarrhythmia Nervous System Diseases
C0686347 BXGD009832 Tardive Dyskinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751257 BXGD010367 Auditory Processing Disorder, Central Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0852733 BXGD010952 Completed Suicide
C0856975 BXGD011127 Autistic behavior Behavior and Behavior Mechanisms
C0871470 BXGD011316 Systolic Pressure
C0917816 BXGD011419 Mental deficiency Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1305855 BXGD012348 Body mass index
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1519383 BXGD013237 Smoking Behaviors Behavior and Behavior Mechanisms
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1833362 BXGD013919 Sleep-wake cycle disturbance
C1836542 BXGD014129 Depressed nasal bridge
C1836830 BXGD014165 Developmental regression Mental Disorders
C1837397 BXGD014227 Severe global developmental delay
C1837402 BXGD014228 Flat occiput
C1837461 BXGD014234 SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
C1844505 BXGD014633 Pointed chin
C1848207 BXGD014916 Poor speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1848701 BXGD014967 Elevated hepatic transaminase
C1853618 BXGD015347 Perivascular spaces
C1854882 BXGD015439 Absent speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1857280 BXGD015691 Infra-orbital crease
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1860247 BXGD015973 Prominent glabella
C1860834 BXGD016006 Infantile muscular hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1865014 BXGD016282 Long philtrum
C1865017 BXGD016283 Thin upper lip vermilion
C1956257 BXGD016623 Pulmonary Stenosis Cardiovascular Diseases
C1961102 BXGD016673 Precursor Cell Lymphoblastic Leukemia Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1970431 BXGD016834 PITT-HOPKINS SYNDROME Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3276036 BXGD018682 High anterior hairline
C3280479 BXGD018830 PITT-HOPKINS-LIKE SYNDROME 2
C3548479 BXGD019120 response to bronchodilator
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3714760 BXGD019432 Drug-induced tardive dyskinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Chemically-Induced Disorders
C3808494 BXGD019548 CHROMOSOME 2p16.3 DELETION SYNDROME
C3894553 BXGD020038 response to simvastatin
C4022908 BXGD021034 Cerebral white matter hypoplasia
C4317045 BXGD022719 Gluten intolerance
C4551583 BXGD023361 Cerebral cortical atrophy
C4721773 BXGD023768 Postoperative cognitive dysfunction
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein