Showing entry for Dual specificity mitogen-activated protein kinase kinase 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009923
Protein NameDual specificity mitogen-activated protein kinase kinase 2
Uniport IdP36507
GeneMAP2K2
Gene Id5605
DomainPkinase
Pfam PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.12 Drug resistance: Antineoplastic hsa01521 EGFR tyrosine kinase inhibitor resistance
6. Human Diseases 6.12 Drug resistance: Antineoplastic hsa01522 Endocrine resistance
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04012 ErbB signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04014 Ras signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04015 Rap1 signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04022 cGMP-PKG signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04024 cAMP signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04066 HIF-1 signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04068 FoxO signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04071 Sphingolipid signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04072 Phospholipase D signaling pathway
4. Cellular Processes 4.1 Transport and catabolism hsa04140 Autophagy - animal
3. Environmental Information Processing 3.2 Signal transduction hsa04150 mTOR signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04151 PI3K-Akt signaling pathway
4. Cellular Processes 4.2 Cell growth and death hsa04210 Apoptosis
4. Cellular Processes 4.2 Cell growth and death hsa04218 Cellular senescence
5. Organismal Systems 5.3 Circulatory system hsa04270 Vascular smooth muscle contraction
3. Environmental Information Processing 3.2 Signal transduction hsa04370 VEGF signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04371 Apelin signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04540 Gap junction
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04550 Signaling pathways regulating pluripotency of stem cells
5. Organismal Systems 5.1 Immune system hsa04620 Toll-like receptor signaling pathway
5. Organismal Systems 5.1 Immune system hsa04650 Natural killer cell mediated cytotoxicity
5. Organismal Systems 5.1 Immune system hsa04660 T cell receptor signaling pathway
5. Organismal Systems 5.1 Immune system hsa04662 B cell receptor signaling pathway
5. Organismal Systems 5.1 Immune system hsa04664 Fc epsilon RI signaling pathway
5. Organismal Systems 5.6 Nervous system hsa04720 Long-term potentiation
5. Organismal Systems 5.6 Nervous system hsa04722 Neurotrophin signaling pathway
5. Organismal Systems 5.6 Nervous system hsa04730 Long-term depression
4. Cellular Processes 4.5 Cell motility hsa04810 Regulation of actin cytoskeleton
5. Organismal Systems 5.2 Endocrine system hsa04910 Insulin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04912 GnRH signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04915 Estrogen signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04916 Melanogenesis
5. Organismal Systems 5.2 Endocrine system hsa04917 Prolactin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04919 Thyroid hormone signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04921 Oxytocin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04926 Relaxin signaling pathway
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04934 Cushing syndrome
6. Human Diseases 6.4 Neurodegenerative diseases hsa05020 Prion diseases
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05135 Yersinia infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05160 Hepatitis C
6. Human Diseases 6.9 Infectious diseases: Viral hsa05161 Hepatitis B
6. Human Diseases 6.9 Infectious diseases: Viral hsa05163 Human cytomegalovirus infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05164 Influenza A
6. Human Diseases 6.9 Infectious diseases: Viral hsa05165 Human papillomavirus infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05166 Human T-cell leukemia virus 1 infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05167 Kaposi sarcoma-associated herpesvirus infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05170 Human immunodeficiency virus 1 infection
6. Human Diseases 6.1 Cancers: Overview hsa05200 Pathways in cancer
6. Human Diseases 6.1 Cancers: Overview hsa05205 Proteoglycans in cancer
6. Human Diseases 6.1 Cancers: Overview hsa05206 MicroRNAs in cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05210 Colorectal cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05211 Renal cell carcinoma
6. Human Diseases 6.2 Cancers: Specific types hsa05213 Endometrial cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05214 Glioma
6. Human Diseases 6.2 Cancers: Specific types hsa05215 Prostate cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05216 Thyroid cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05218 Melanoma
6. Human Diseases 6.2 Cancers: Specific types hsa05219 Bladder cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05220 Chronic myeloid leukemia
6. Human Diseases 6.2 Cancers: Specific types hsa05221 Acute myeloid leukemia
6. Human Diseases 6.2 Cancers: Specific types hsa05223 Non-small cell lung cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05224 Breast cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05225 Hepatocellular carcinoma
6. Human Diseases 6.2 Cancers: Specific types hsa05226 Gastric cancer
6. Human Diseases 6.1 Cancers: Overview hsa05230 Central carbon metabolism in cancer
6. Human Diseases 6.1 Cancers: Overview hsa05231 Choline metabolism in cancer
6. Human Diseases 6.1 Cancers: Overview hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0000187 activation of MAPK activity
Biological Process GO:0070371 ERK1 and ERK2 cascade
Biological Process GO:0000165 MAPK cascade
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0036289 peptidyl-serine autophosphorylation
Biological Process GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA
Biological Process GO:0071902 positive regulation of protein serine/threonine kinase activity
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:2000641 regulation of early endosome to late endosome transport
Biological Process GO:0090170 regulation of Golgi inheritance
Biological Process GO:0032872 regulation of stress-activated MAPK cascade
molecular function GO:0005524 ATP binding
molecular function GO:0004708 MAP kinase kinase activity
molecular function GO:0005078 MAP-kinase scaffold activity
molecular function GO:0046872 metal ion binding
molecular function GO:0030165 PDZ domain binding
molecular function GO:0004712 protein serine/threonine/tyrosine kinase activity
molecular function GO:0043539 protein serine/threonine kinase activator activity
molecular function GO:0004674 protein serine/threonine kinase activity
molecular function GO:0004713 protein tyrosine kinase activity
molecular function GO:0097110 scaffold protein binding
cellular component GO:0005911 cell-cell junction
cellular component GO:0009898 cytoplasmic side of plasma membrane
cellular component GO:0005829 cytosol
cellular component GO:0005769 early endosome
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005576 extracellular region
cellular component GO:0005925 focal adhesion
cellular component GO:0005794 Golgi apparatus
cellular component GO:0005770 late endosome
cellular component GO:0005874 microtubule
cellular component GO:0005739 mitochondrion
cellular component GO:0005634 nucleus
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0005778 peroxisomal membrane
Reactome
Pathway Id Pathway Name
R-HSA-112409 RAF-independent MAPK1/3 activation
R-HSA-112411 MAPK1 (ERK2) activation
R-HSA-1266738 Developmental Biology
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-166520 Signaling by NTRKs
R-HSA-168256 Immune System
R-HSA-169893 Prolonged ERK activation events
R-HSA-170968 Frs2-mediated activation
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-187687 Signalling to ERKs
R-HSA-373760 L1CAM interactions
R-HSA-422475 Axon guidance
R-HSA-445144 Signal transduction by L1
R-HSA-5210891 Uptake and function of anthrax toxins
R-HSA-5339562 Uptake and actions of bacterial toxins
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-5663205 Infectious disease
R-HSA-5673000 RAF activation
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5674135 MAP2K and MAPK activation
R-HSA-5674499 Negative feedback regulation of MAPK pathway
R-HSA-5675221 Negative regulation of MAPK pathway
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants
R-HSA-6802949 Signaling by RAS mutants
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
R-HSA-6802957 Oncogenic MAPK signaling
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9607240 FLT3 Signaling
R-HSA-9649948 Signaling downstream of RAS mutants
R-HSA-9652169 Signaling by MAP2K mutants
R-HSA-9656223 Signaling by RAF1 mutants
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003130 BXGD000183 Anoxia Pathological Conditions, Signs and Symptoms
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0005890 BXGD000345 Body Height
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0008073 BXGD000518 Developmental Disabilities Mental Disorders
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0010606 BXGD000677 Adenoid Cystic Carcinoma Neoplasms
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0016842 BXGD001083 Congenital pectus excavatum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0017168 BXGD001101 Gastroesophageal reflux disease Digestive System Diseases
C0017638 BXGD001132 Glioma Neoplasms
C0018817 BXGD001235 Atrial Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018920 BXGD001246 Hemangioma, Cavernous Neoplasms; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0019618 BXGD001339 Histiocytosis Hemic and Lymphatic Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020255 BXGD001369 Hydrocephalus Nervous System Diseases
C0020295 BXGD001372 Hydronephrosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0020458 BXGD001393 Hyperhidrosis disorder Skin and Connective Tissue Diseases
C0020534 BXGD001421 Orbital separation excessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0020757 BXGD001466 Ichthyoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0021841 BXGD001519 Intestinal Neoplasms Digestive System Diseases; Neoplasms
C0023418 BXGD001642 leukemia Neoplasms
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023508 BXGD001675 White Blood Cell Count procedure
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024236 BXGD001752 Lymphedema Hemic and Lymphatic Diseases
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027092 BXGD001971 Myopia Eye Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027809 BXGD002040 Neurilemmoma Neoplasms
C0027832 BXGD002048 Neurofibromatosis 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0028326 BXGD002075 Noonan Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Cardiovascular Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0041409 BXGD002924 Turner Syndrome, Male Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Cardiovascular Diseases
C0151526 BXGD003432 Premature Birth Female Urogenital Diseases and Pregnancy Complications
C0151529 BXGD003433 Prolonged bleeding time
C0151611 BXGD003447 Electroencephalogram abnormal Nervous System Diseases
C0151779 BXGD003473 Cutaneous Melanoma Neoplasms; Skin and Connective Tissue Diseases
C0151908 BXGD003502 Dry skin Skin and Connective Tissue Diseases
C0152421 BXGD003586 Macrotia
C0158465 BXGD003887 Acquired cubitus valgus
C0175704 BXGD004010 LEOPARD Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Cardiovascular Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0221217 BXGD004408 Neck webbing Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0221354 BXGD004446 Frontal bossing Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0221355 BXGD004447 Macrocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0231274 BXGD004490 Intolerant of heat
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0239676 BXGD004989 High forehead
C0240635 BXGD005047 Byzanthine arch palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Stomatognathic Diseases
C0241074 BXGD005078 Hyperextensible skin
C0241654 BXGD005104 Abnormal heart valve morphology Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0263490 BXGD005314 Brittle hair
C0266470 BXGD005678 Cerebellar Hypoplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0272138 BXGD006308 Erythroblastosis
C0278510 BXGD006526 Childhood Medulloblastoma Neoplasms
C0278701 BXGD006566 Gastric Adenocarcinoma Digestive System Diseases; Neoplasms
C0278876 BXGD006607 Adult Medulloblastoma Neoplasms
C0278883 BXGD006614 Metastatic melanoma Neoplasms
C0281361 BXGD006774 Adenocarcinoma of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0334586 BXGD007126 Pleomorphic Xanthoastrocytoma Neoplasms
C0338502 BXGD007192 Hypoplasia of the optic nerve Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C0344482 BXGD007678 Hypoplasia of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349588 BXGD007933 Short stature
C0423110 BXGD008471 Downward slant of palpebral fissure
C0423113 BXGD008473 Telecanthus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0423867 BXGD008517 Fine hair
C0424605 BXGD008535 Developmental delay (disorder) Mental Disorders
C0431448 BXGD008691 Absent eyebrow Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0432103 BXGD008722 Submucous cleft of hard palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C0521525 BXGD009139 Short neck
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0553586 BXGD009401 Cafe-au-lait macules with pulmonary stenosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0576093 BXGD009525 Knee joint valgus deformity Musculoskeletal Diseases
C0581342 BXGD009560 Redundant skin Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0587248 BXGD009617 Costello syndrome (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678230 BXGD009750 Congenital Epicanthus
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0685938 BXGD009829 Malignant neoplasm of gastrointestinal tract Digestive System Diseases; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0751606 BXGD010523 Adult Acute Lymphocytic Leukemia
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1096666 BXGD011638 Thyroid cancer metastatic Neoplasms; Endocrine System Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1275081 BXGD012056 Cardio-facio-cutaneous syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Cardiovascular Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1328931 BXGD012477 Multiple lentigines
C1527404 BXGD013289 Female Pseudo-Turner Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Cardiovascular Diseases
C1832348 BXGD013831 Slow-growing hair
C1833340 BXGD013918 Synostotic Posterior Plagiocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1836047 BXGD014074 Long face
C1836542 BXGD014129 Depressed nasal bridge
C1837732 BXGD014261 Thickened helices
C1837770 BXGD014270 Sparse hair
C1839758 BXGD014402 Narrow forehead
C1840077 BXGD014434 Anteverted nostril
C1843181 BXGD014564 Noonan syndrome-like disorder with loose anagen hair Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C1845847 BXGD014760 Coarse facial features Pathological Conditions, Signs and Symptoms
C1849340 BXGD015039 Long palpebral fissure
C1854114 BXGD015383 Short nose
C1854418 BXGD015402 Biparietal narrowing
C1855728 BXGD015536 Low posterior hairline
C1856660 BXGD015629 Abnormality of the helix
C1857486 BXGD015710 Low-set, posteriorly rotated ears
C1857539 BXGD015716 Deep palmar crease
C1860493 BXGD015987 Abnormality of the sternum
C1861869 BXGD016088 Underdeveloped supraorbital ridges
C1861975 BXGD016095 Cafe au lait spots, multiple Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C1865014 BXGD016282 Long philtrum
C1866231 BXGD016388 Full cheeks
C1867873 BXGD016473 Failure to thrive in infancy
C1956257 BXGD016623 Pulmonary Stenosis Cardiovascular Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1963094 BXGD016681 Dry Skin, CTCAE
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2674608 BXGD017250 Feeding difficulties in infancy
C2919142 BXGD017867 Short Stature, CTCAE
C2930995 BXGD017931 Dyschromatosis universalis hereditaria Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C2931482 BXGD018028 Neurofibromatosis-Noonan syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Nervous System Diseases; Cardiovascular Diseases
C3164445 BXGD018529 Abnormality of aortic valve
C3501846 BXGD019029 Noonan-Like Syndrome With Loose Anagen Hair Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Cardiovascular Diseases
C3551426 BXGD019146 Dystrophic fingernails
C3551431 BXGD019147 Sparse or absent eyelashes
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3809007 BXGD019569 CARDIOFACIOCUTANEOUS SYNDROME 4
C3899645 BXGD020087 Childhood Pleomorphic Xanthoastrocytoma
C4021242 BXGD020592 Hypoplasia of the zygomatic bone
C4021264 BXGD020604 Abnormal ventricular septum morphology Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C4021527 BXGD020654 Abdominal wall muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C4021797 BXGD020787 Abnormality of the thorax
C4021956 BXGD020839 Aplasia/Hypoplasia of the eyebrow
C4021976 BXGD020852 Abnormality of the lymphatic system
C4022662 BXGD020948 Abnormality of lateral ventricle
C4022755 BXGD020984 Functional abnormality of the gastrointestinal tract
C4024878 BXGD021453 Generalized hyperpigmentation Skin and Connective Tissue Diseases
C4024890 BXGD021458 Excessive wrinkled skin
C4025662 BXGD021716 Abnormality of the ulna
C4025790 BXGD021791 Specific learning disability
C4025846 BXGD021826 Abnormality of vision
C4551583 BXGD023361 Cerebral cortical atrophy
C4551602 BXGD023369 Noonan Syndrome 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Cardiovascular Diseases
C4551675 BXGD023384 Keratoderma, Palmoplantar Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000933 (-)-Arctigenin 372.41
BXGC0001940 Daphnetin 178.14
BXGC0002071 Apigenin 270.24
BXGC0002588 Magnesium 24.31
BXGC0005624 Genistein 270.24
BXGC0005683 Quercetin 302.24
BXGC0007052 Olomoucine 298.34
BXGC0012706 4-hydroxy-5-nitrophenyl acetic acid 197.03
BXGC0013582 Curcumin 368.13
BXGC0020745 hecogenin 430.31
BXGC0020911 Debromohymenialdisine 245.09
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0042870 Piceatannol 244.07
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
BXGC0050099 (2E,5S,6S,8Z,11S)-5,6,15-Trihydroxy-17-Methoxy-11-Methyl-12-Oxabicyclo[12.4.0]Octadeca-1(14),2,8,15,17-Pentaene-7,13-Dione 362.14
BXGC0051995 Wedelolactone 314.04
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein